Diterpenoid quinones from the Salvia miltiorrhiza and their lung protective activity

Seven new diterpenoids quinones (1–6), together with five known ones (7–11), were isolated from the roots of Salvia miltiorrhiza Bunge. Their structures were elucidated by using 1D and 2D NMR data, while the relative and absolute configurations were confirmed by interpretations of the NOESY correlat...

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Published in:Fitoterapia 2023-06, Vol.167, p.105474, Article 105474
Main Authors: Ren, Ying-Jie, Cao, Yan-Gang, Zeng, Meng-Nan, Zhang, Qin-Qin, Liu, Yan-Ling, He, Chen, Chen, Xu, Fan, Xi-Ling, Xiang-Da, Li, Zheng, Xiao-Ke, Feng, Wei-Sheng
Format: Article
Language:English
Subjects:
BEAS-2B cells
Diterpenoid quinones
LPS
Salvia miltiorrhiza
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Summary:Seven new diterpenoids quinones (1–6), together with five known ones (7–11), were isolated from the roots of Salvia miltiorrhiza Bunge. Their structures were elucidated by using 1D and 2D NMR data, while the relative and absolute configurations were confirmed by interpretations of the NOESY correlations and comparison of the experimental and calculated ECD spectra. In the evaluation of bioactivities, salviamilthiza C (3), significantly increased cell viability and decreased the expression of IL-1β in LPS-induced BEAS-2B cells. [Display omitted] •Seven new diterpenoid quinones were isolated from the dried roots of Salvia miltiorrhiza.•Their structures were elucidated by NMR and mass spectrometry.•All the isolated compounds were evaluated in vitro for their lung-protective effects.
ISSN:0367-326X
DOI:10.1016/j.fitote.2023.105474