Polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii Hance and their anti-inflammatory activity

Phytochemical investigation of Hypericum sampsonii Hance resulted in the isolation of thirty-five polycyclic polyprenylated acylphloroglucinols including six new ones (1, 3, 5, and 15–17). Their structures were elucidated by UV, IR, NMR, HRESIMS, and calculated ECD analysis. Some compounds were eval...

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Bibliographic Details
Published in:Fitoterapia 2023-09, Vol.169, p.105610, Article 105610
Main Authors: Li, Yanzhen, Wang, Mingqiang, Su, Jianhui, Wang, Yuanyuan, Zhao, Zhongxiang, Sun, Zhanghua
Format: Article
Language:English
Subjects:
Anti-inflammatory activity
Hypericum sampsonii Hance
Polycyclic polyprenylated acylphloroglucinols
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Summary:Phytochemical investigation of Hypericum sampsonii Hance resulted in the isolation of thirty-five polycyclic polyprenylated acylphloroglucinols including six new ones (1, 3, 5, and 15–17). Their structures were elucidated by UV, IR, NMR, HRESIMS, and calculated ECD analysis. Some compounds were evaluated for their anti-inflammatory effects in LPS-induced RAW264.7 cells. Compounds 1 and 26 showed significant inhibitory effects on LPS-induced NO production, and markedly suppressed the protein expression of iNOS and COX-2 in LPS-activated RAW264.7 cells. [Display omitted]
ISSN:0367-326X
DOI:10.1016/j.fitote.2023.105610