Bioactive diterpenoids isolated from the twigs and leaves of Casearia velutina

Nine previously undescribed clerodane-type diterpenoids (1–9), named caseabalanspenes A-I, along with six know compounds (10–15), were isolated from the twigs and leaves of Casearia velutina. Spectroscopic data (1D and 2D NMR) analysis permitted the definition of their structures and then determinat...

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Bibliographic Details
Published in:Fitoterapia 2023-12, Vol.171, p.105654, Article 105654
Main Authors: Li, Yan, Li, Jian-Mei, Xu, Yao-Jun, Zu, Xue-Dan, He, Han, Sun, Yan, Zhang, Rui-Han, Zhang, Xing-Jie, Li, Xiao-Li, Xiao, Wei-Lie
Format: Article
Language:English
Subjects:
Anti-inflammasome activity
Casearia velutina
Clerodane diterpenoids
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Summary:Nine previously undescribed clerodane-type diterpenoids (1–9), named caseabalanspenes A-I, along with six know compounds (10–15), were isolated from the twigs and leaves of Casearia velutina. Spectroscopic data (1D and 2D NMR) analysis permitted the definition of their structures and then determination of the molecular formula of the compound by high resolution mass spectrometry (HR-ESI-MS). It is worth noting that compound 7 contains N- heterocycle. Compounds 1–8 were tested the anti-inflammasome activity, and compound 3 exhibited potent activity and decreased LDH level in a dose-dependent manner, with IC50 values of 2.90 μM. [Display omitted] •Nine undescribed clerodane diterpenoids were isolated from Casearia velutina.•Their structures were determined by 1D, 2D-NMR and HR-ESI-MS analyses.•The structure of compound 7 contains an N-heterocycle.•Compound 3 exhibited NLRP3-inflammasome inhibitory activity with IC50 values of 2.90 μM.
ISSN:0367-326X
DOI:10.1016/j.fitote.2023.105654