Four new phenolic constituents from the roots of Rumex dentatus L

Four new phenolic compounds, including two naphthalenes, musizin-8-O-β-D-(6′-O-malonyl-3′′-methoxy)glucopyranoside (1) and 2-acetyl-3-methyl-1,4-naphtho-quinone-8-O-β-D-glucopyranoside (2), one chromone, (2′R)-7-hydroxy-2-(2′-hydroxypropyl)-5-methyl acetate chromone (3), and one xanthone, 2,8-dimeth...

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Bibliographic Details
Published in:Fitoterapia 2023-10, Vol.170, p.105657, Article 105657
Main Authors: Li, Jing-Juan, Zhu, Hong-Tao, Eshbakova, Komila Alibekovna, Zhang, Man, Wang, Dong, Zhang, Ying-Jun
Format: Article
Language:English
Subjects:
Antifungal activity
Naphthalenes
Polygonaceae
Rumex dentatus
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Summary:Four new phenolic compounds, including two naphthalenes, musizin-8-O-β-D-(6′-O-malonyl-3′′-methoxy)glucopyranoside (1) and 2-acetyl-3-methyl-1,4-naphtho-quinone-8-O-β-D-glucopyranoside (2), one chromone, (2′R)-7-hydroxy-2-(2′-hydroxypropyl)-5-methyl acetate chromone (3), and one xanthone, 2,8-dimethyl-3,6-dihydroxyxanthone (4) were isolated from the roots of Rumex dentatus L. (Polygonaceae). In addition, five known including four naphthalenes (5–8) and one chromone (9) were also obtained. Their structures were determined by means of extensive spectroscopic analysis and acidic hydrolysis. Compound 1 showed moderate antifungal activity against Epidermophyton floccosum, with inhibitory rate of 39.539 ± 0.412% at a concentration of 100 μM. [Display omitted]
ISSN:0367-326X
DOI:10.1016/j.fitote.2023.105657