New steroidal saponins from the aerial parts of Paris polyphylla var. yunnanensis and their effects on blood coagulation

Five new steroidal saponins, paripolins D-H (1–5), and 6 known compounds (6–11) were isolated from the aerial parts of Paris polyphylla var. yunnanensis. The structures of 1–5 were determined using spectroscopic analyses in conjunction with acid hydrolysis. It is for the first time to report the 12-...

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Bibliographic Details
Published in:Fitoterapia 2024-04, Vol.174, p.105833, Article 105833
Main Authors: Nie, Wei, Zhang, Hong-yan, Ma, Yan-xia, Wan, Jin-Fu, Feng, Li-Ping, Cui, Tao, Li, Qian
Format: Article
Language:English
Subjects:
Anticoagulant
Paris polyphylla var. yunnanensis
Plasma recalcification time
Procoagulant
Steroidal saponins
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Summary:Five new steroidal saponins, paripolins D-H (1–5), and 6 known compounds (6–11) were isolated from the aerial parts of Paris polyphylla var. yunnanensis. The structures of 1–5 were determined using spectroscopic analyses in conjunction with acid hydrolysis. It is for the first time to report the 12-hydroxysteroidal saponins from the genus Paris. The effect of all isolated compounds on blood coagulation was determined in vitro using the plasma recalcification time method. Compounds 1 and 2 showed potent procoagulant activity, and 5–11 exhibited significant anticoagulant activity. [Display omitted] •Five undescribed and six known steroidal saponins were isolated from Paris polyphylla var. yunnanensis.•The activity of isolated compounds on blood coagulation was evaluated.•Compounds 1 and 2 showed notable procoagulant activity.•Compounds 5–11 exhibited significant anticoagulant activity.
ISSN:0367-326X
DOI:10.1016/j.fitote.2024.105833