Bioactivities of morroniside: A comprehensive review of pharmacological properties and molecular mechanisms

• Published in: Fitoterapia 2024-06, Vol.175, p.105896, Article 105896
• Main Authors: Bhuia, Md. Shimul, Chowdhury, Raihan, Ara, Iffat, Mamun, Md, Rouf, Razina, Khan, Muahmmad Ali, Uddin, Shaikh Jamal, Shakil, Md. Abdul Kader, Habtemariam, Solomon, Ferdous, Jannatul, Calina, Daniela, Sharifi-Rad, Javad, Islam, Muhammad Torequl
• Format: Article
• Language: English
• Subjects: Iridoid glycoside; Molecular mechanisms of action; Morronisde; Pharmacological activities
• ISSN: 0367-326X
• DOI: 10.1016/j.fitote.2024.105896

Morroniside (MOR) is an iridoid glycoside and the main active principle of the medicinal plant, Cornus officinalis Sieb. This phytochemical is associated with numerous health benefits due to its antioxidant properties. The primary objective of the present study was to assess the pharmacological effects and underlying mechanisms of MOR, utilizing published data obtained from literature databases. Data collection involved accessing various sources, including PubMed/Medline, Scopus, Science Direct, Google Scholar, Web of Science, and SpringerLink. Our findings demonstrate that MOR can be utilized for the treatment of several diseases and disorders, as numerous studies have revealed its significant therapeutic activities. These activities encompass anti-inflammatory, antidiabetic, lipid-lowering capability, anticancer, trichogenic, hepatoprotective, gastroprotective, osteoprotective, renoprotective, and cardioprotective effects. MOR has also shown promising benefits against various neurological ailments, including Alzheimer's disease, Parkinson's disease, spinal cord injury, cerebral ischemia, and neuropathic pain. Considering these therapeutic features, MOR holds promise as a lead compound for the treatment of various ailments and disorders. However, further comprehensive preclinical and clinical trials are required to establish MOR as an effective and reliable therapeutic agent. [Display omitted] •Morroniside (MOR) is an iridoid glycoside, the main active phytochemical found in Cornus officinalis Sieb.•MOR is associated with numerous health benefits due to its antioxidant properties•Effects: anti-inflammatory, antidiabetic, anticancer, hepatoprotective, osteoprotective, cardioprotective•Further clinical studies are required to establish MOR as an effective and reliable therapeutic agent