Linderangolides A−D, four new butanolides from the roots of Lindera angustifolia and their cytotoxic activity

Four undescribed butanolides, linderangolides A–D (1–4), along with four known congeners, lincomolide A (5), (−)-epilitsenolide C2 (6), (−)-epilitsenolide C1 (7) and litseakolide H (8), were isolated from the roots of Lindera angustifolia. The planar structures of 1–4 were elucidated based on extens...

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Bibliographic Details
Published in:Fitoterapia 2024-10, Vol.178, p.106180, Article 106180
Main Authors: Wei, Jieqin, Guo, Jiaqi, Shi, Qi, Wang, Yiwen, Zhou, Manjia, Ren, Hangjie, Ma, Runchao, Ying, Jiani, Meng, Xiongyu, Qin, Lupin, Li, Huaqiang
Format: Article
Language:English
Subjects:
Butanolides
Cytotoxic activity
Lindera angustifolia
Lindera Thunb
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Summary:Four undescribed butanolides, linderangolides A–D (1–4), along with four known congeners, lincomolide A (5), (−)-epilitsenolide C2 (6), (−)-epilitsenolide C1 (7) and litseakolide H (8), were isolated from the roots of Lindera angustifolia. The planar structures of 1–4 were elucidated based on extensive spectroscopic analyses, the relative and absolute configurations of 1–4 were determined by the NOESY spectra and the comparison of calculated and experimental ECD. The cytotoxic activities of all isolated compounds were tested, 4 showed inhibitory activity against SGC-7 cells with IC50 value of 6.62 μM. [Display omitted]
ISSN:0367-326X
DOI:10.1016/j.fitote.2024.106180