Gastroprotective effect of a type I arabinogalactan from soybean meal

A highly purified type I arabinogalactan (AG) from soybean meal was prepared. It contained galactose, arabinose, galacturonic acid and rhamnose in a 52:41:4:3 molar ratio and had M w 124,000 g/mol. Methylation analysis and 13C NMR spectroscopy indicated that AG is constituted by a (1→4)-linked β-Gal...

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Bibliographic Details
Published in:Food chemistry 2009-07, Vol.115 (2), p.687-690
Main Authors: Cipriani, Thales R., Mellinger, Caroline G., Bertolini, Maria L.C., Baggio, Cristiane H., Freitas, Cristina S., Marques, Maria Consuelo A., Gorin, Philip A.J., Sassaki, Guilherme L., Iacomini, Marcello
Format: Article
Language:English
Subjects:
animal models
Anti-ulcer activity
Arabinogalactan
arabinogalactans
Biological and medical sciences
chemical structure
Food industries
Fruit and vegetable industries
Fundamental and applied biological sciences. Psychology
human diseases
lesions (animal)
phytochemicals
protective effect
rats
Soybean
soybean meal
stomach
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Summary:A highly purified type I arabinogalactan (AG) from soybean meal was prepared. It contained galactose, arabinose, galacturonic acid and rhamnose in a 52:41:4:3 molar ratio and had M w 124,000 g/mol. Methylation analysis and 13C NMR spectroscopy indicated that AG is constituted by a (1→4)-linked β-Gal p main chain with substituents of α-Ara f at O-3, which are in turn substituted at O-5, O-3,5, and O-2,5. It is probably linked to O-4 of some rhamnosyl units of a type I rhamnogalacturonan, formed by repeating (1→4)-α-D-Gal pA-(1→2)-α-L-Rha p groups. AG significantly inhibited ethanol-induced gastric lesions in rats at an ED 50 of 35 mg/kg, indicating that it has a gastroprotective effect.
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2008.12.017