Protective effects of taurine against hepatic abnormality in NZB/W F1 mice fed a hypercholesterolemic diet

A hypercholesterolemic diet has been associated with the hepatic abnormalities and the pathological processes of systemic lupus erythematosus (SLE). To investigate the effects of taurine on the hepatic abnormality in SLE, NZB/W F1 mice were used as an animal model by receiving control, cholesterol,...

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Bibliographic Details
Published in:Food chemistry 2010-03, Vol.119 (1), p.62-68
Main Authors: Hsu, Tsai-Ching, Chen, Yi-Chen, Tsai, Chun-Chou, Wu, Jen-Huang, Li, Sin-Lun, Tzang, Bor-Show
Format: Article
Language:English
Subjects:
alanine transaminase
animal models
animal stress
aspartate transaminase
Biological and medical sciences
blood lipids
blood pressure
body weight
C-reactive protein
cholesteremic effect
cholesterol
diet
dietary supplements
disease course
Feeding. Feeding behavior
Food industries
Fundamental and applied biological sciences. Psychology
Hepatic abnormality
hepatoprotective effect
hypercholesterolemia
Hypercholesterolemic diet
liver
liver diseases
lupus erythematosus
mice
NZB/W F1
protein synthesis
Systemic lupus erythematosus (SLE)
Taurine
tissue weight
triacylglycerols
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:A hypercholesterolemic diet has been associated with the hepatic abnormalities and the pathological processes of systemic lupus erythematosus (SLE). To investigate the effects of taurine on the hepatic abnormality in SLE, NZB/W F1 mice were used as an animal model by receiving control, cholesterol, or cholesterol + taurine diets, respectively. Reductions ( P < 0.05) of liver-to-body weight ratio, lipid deposit, mean arterial pressure, serum total cholesterol (TC), triacylglycerol (TAG), AST, ALT and hepatic CRP levels were detected in the cholesterol + taurine group as compared to those of the cholesterol group. In addition, stress-related molecules in livers, including HSP70, HSP90, MMP9 and iNOS, were also lower ( P < 0.05) in the cholesterol + taurine group compared to the cholesterol group. These findings demonstrated the protective effects of taurine on the hepatic abnormality in NZB/W F1 mice fed a hypercholesterolemic diet and may suggest taurine as a dietary supplementation for SLE patients.
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2009.05.088