Constituents isolated from Glehnia littoralis suppress proliferations of human cancer cells and MMP expression in HT1080 cells

Crude extract and solvent-partitioned fraction of Glehnia littoralis were found to possess different anti-proliferative effects against AGS, HT1080 and U937 human cancer cells. The crude extracts and solvent fractions dose-dependently inhibited cell proliferation. Especially, n-hexane and 85% aqueou...

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Bibliographic Details
Published in:Food chemistry 2010-05, Vol.120 (2), p.385-394
Main Authors: Kong, Chang-Suk, Um, Young Ran, Lee, Jung Im, Kim, You Ah, Yea, Sung Su, Seo, Youngwan
Format: Article
Language:English
Subjects:
alcohols
anticarcinogenic activity
Biological and medical sciences
Cancer cells
cell lines
cell proliferation
chemical composition
cytotoxicity
dose response
fibrosarcoma
Food industries
Fundamental and applied biological sciences. Psychology
Furanocoumarins
gene expression
gene expression regulation
Glehnia
Glehnia littoralis
Glucopyranosides
glycosides
hexane
human diseases
leukemia
matrix metalloproteinase
medicinal plants
metalloproteinases
methanol
MMP
plant extracts
Polyacetylenic alcohols
psoralens
solvents
stomach neoplasms
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Summary:Crude extract and solvent-partitioned fraction of Glehnia littoralis were found to possess different anti-proliferative effects against AGS, HT1080 and U937 human cancer cells. The crude extracts and solvent fractions dose-dependently inhibited cell proliferation. Especially, n-hexane and 85% aqueous MeOH fractions exhibited comparatively higher anti-proliferative effects and reduced expressions of Bcl-2, COX-2 and iNOS genes. Systematic separation of all solvent fractions by chromatographic methods led to the isolation of three glucopyranosides, four furanocoumarins and two polyacetylenic alcohols. All the nine compounds were evaluated for their inhibitory effects against both proliferation of human cancer cells and expressions of MMP-2 and -9 in HT1080 cells. Two polyacetylenic alcohols exerted the highest inhibitory activity against both human cancer cell lines, and MMP-2 and -9. These results suggest that G. littoralis may possibly be used as a valuable chemopreventive agent or food supplement for reducing cancer risk.
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2009.09.096