Anti-hyperglycemic effects of sugar maple Acer saccharum and its constituent acertannin

The anti-hyperglycemic effects of the leaves of sugar maple, Acer saccharum and purification and identification of the active compound were investigated. Extracts of the leaves showed a potent inhibitory effect on α-glucosidase in both in vivo and in vitro experiments. In vitro enzyme-inhibitory ass...

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Bibliographic Details
Published in:Food chemistry 2010-11, Vol.123 (2), p.390-394
Main Authors: Honma, Atsushi, Koyama, Tomoyuki, Yazawa, Kazunaga
Format: Article
Language:English
Subjects:
2,6-di- O-galloyl-1,5-anhydro- d-glucitol
Acer saccharum
Acertannin
Biological and medical sciences
Diabetes mellitus
Food industries
Fundamental and applied biological sciences. Psychology
α-Glucosidase inhibitory effect
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Summary:The anti-hyperglycemic effects of the leaves of sugar maple, Acer saccharum and purification and identification of the active compound were investigated. Extracts of the leaves showed a potent inhibitory effect on α-glucosidase in both in vivo and in vitro experiments. In vitro enzyme-inhibitory assay-guided fractionation of the crude extract gave active compound, acertannin (2,6-di- O-galloyl-1,5-anhydro- d-glucitol) by spectroscopic analysis. This is the first report that acertannin from A. saccharum may be used in diabetes care.
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2010.04.052