Antioxidant and antiglycemic potential of Peltophorum pterocarpum plant parts

• Published in: Food chemistry 2011-12, Vol.129 (4), p.1355-1361
• Main Authors: Manaharan, Thamilvaani, Teng, Ling Lai, Appleton, David, Ming, Cheng Hwee, Masilamani, Theanmalar, Palanisamy, Uma Devi
• Format: Article
• Language: English
• Subjects: Advanced glycation end-products inhibitor; Aldose reductase inhibitor; antioxidant activity; Biological and medical sciences; Food industries; free radical scavengers; Fundamental and applied biological sciences. Psychology; in vivo studies; leaf extracts; Peltophorum; Peltophorum pterocarpum; plant anatomy; α-Amylase inhibitor; α-Glucosidase inhibitor
• ISSN: 0308-8146; 1873-7072
• DOI: 10.1016/j.foodchem.2011.05.041

► Peltophorum pterocarpum plant parts exhibit free radical scavenging activity. ► P. pterocarpum plant parts also inhibit carbohydrate hydrolyzing enzymes. ► Its leaf extracts prevented polyol and advance glycated end product formation. ► Quercetin-3-O-β-d-Galactopyranoside is the active principle in the leaf extracts. ► Concentration of active principle in leaf extract was 18.2%. The leaf and bark extracts of Peltophorum pterocarpum were evaluated for their DPPH, ABTS, and galvinoxyl radicals scavenging activity, phenolic content, α-glucosidase, α-amylase and aldose reductase inhibition, and advanced glycation end-products formation inhibition activities. These extracts showed a far more significant antiglycemic activity compared to the commercial carbohydrate inhibitor, acarbose. The active compound in P. pterocarpum leaf extracts was identified to be quercetin-3-O-β-d-galactopyranoside. Our findings provide a strong rationale for further in vivo studies and to establish P. pterocarpum’s capability as an antiglycemic agent.