Determination of parabens using two microextraction methods coupled with capillary liquid chromatography-UV detection

•Parabens were extracted from foods, cosmetics, and pharmaceuticals by two methods.•VA-DLLME-SFO reduced the consumption of toxic solvents and extraction times.•SA-CPE allowed facile recovery of the extraction phase through salt addition.•Both methods were coupled with capillary LC-UV to decrease wa...

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Bibliographic Details
Published in:Food chemistry 2018-02, Vol.241, p.411-418
Main Authors: Chen, Chen-Wen, Hsu, Wen-Chan, Lu, Ya-Chen, Weng, Jing-Ru, Feng, Chia-Hsien
Format: Article
Language:English
Subjects:
Capillary liquid chromatography-UV
Chromatography, High Pressure Liquid
Cosmetics
Floating organic drop
Liquid Phase Microextraction
Paraben
Parabens - analysis
Preservatives, Pharmaceutical
Salt-assisted cloud point extraction
Solidification
Vortex-assisted dispersive liquid-liquid microextraction
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Summary:•Parabens were extracted from foods, cosmetics, and pharmaceuticals by two methods.•VA-DLLME-SFO reduced the consumption of toxic solvents and extraction times.•SA-CPE allowed facile recovery of the extraction phase through salt addition.•Both methods were coupled with capillary LC-UV to decrease waste generation.•This method exhibited good linearity, precision, and accuracy. Parabens are common preservatives and environmental hormones. As such, possible detrimental health effects could be amplified through their widespread use in foods, cosmetics, and pharmaceutical products. Thus, the determination of parabens in such products is of particular importance. This study explored vortex-assisted dispersive liquid-liquid microextraction techniques based on the solidification of a floating organic drop (VA-DLLME-SFO) and salt-assisted cloud point extraction (SA-CPE) for paraben extraction. Microanalysis was performed using a capillary liquid chromatography-ultraviolet detection system. These techniques were modified successfully to determine four parabens in 19 commercial products. The regression equations of these parabens exhibited good linearity (r2=0.998, 0.1–10μg/mL), good precision (RSD
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2017.09.031