Mesoporous molecularly imprinted polymer core@shell hybrid silica nanoparticles as adsorbent in microextraction by packed sorbent for multiresidue determination of pesticides in apple juice

• Published in: Food chemistry 2021-05, Vol.345, p.128745, Article 128745
• Main Authors: Dinali, Laíse Aparecida Fonseca, de Oliveira, Hanna Leijoto, Teixeira, Leila Suleimara, de Souza Borges, Warley, Borges, Keyller Bastos
• Format: Article
• Language: English
• Subjects: Adsorption; Core–shell materials; Food Analysis - methods; Food Contamination - analysis; Fruit and Vegetable Juices - analysis; HPLC; Malus - chemistry; Microextraction by packed sorbent; Molecularly imprinted polymer; Molecularly Imprinted Polymers - chemistry; Nanoparticles - chemistry; Pesticide Residues - analysis; Pesticide Residues - isolation & purification; Pesticides; Porosity; Silica; Silicon Dioxide - chemistry; Solvents - chemistry; Water - chemistry
• ISSN: 0308-8146; 1873-7072
• DOI: 10.1016/j.foodchem.2020.128745

[Display omitted] •Production of a mesoporous MIP synthesized on the surface of silica nanoparticles.•Core@mMIP showed excellent selectivity for the pesticides studied in apple juice.•Innovative association of the core@mMIP with MEPS for pesticide extraction.•New method for pesticides determination based on MEPS and HPLC/UV.•Method was validated and successfully applied in real juice samples. In this work, we report the synthesis of a mesoporous molecularly imprinted polymer on the surface of silica nanoparticles (core@mMIP) to be applied as adsorbent in microextraction by packed sorbent (MEPS) for selective determination of pesticides in apple juice. The core@mMIP was properly characterized, showing good adhesion of the polymer to the silica core. The best extraction conditions were: 200 µL of ultrapure water as washing solvent, 150 µL of acetonitrile as eluent, 100 µL of sample at pH 2.5, five draw-eject cycles and 8 mg of adsorbent. Thereby, recoveries of 96.12 ± 1.05%, 76.88 ± 6.18% and 76.18 ± 5.57% were obtained for pyriproxyfen (PPX), deltamethrin (DTM) and etofenprox (ETF), respectively. After validation, the method presented linearity in the range of 0.02–10 µg mL−1 (r > 0.99), limit of detection of 0.005 µg mL−1, satisfactory selectivity, and proper precision and accuracy. The method was successfully applied real samples of processed and fresh apple juice.