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Novel γ-cyclodextrin-metal–organic frameworks for encapsulation of curcumin with improved loading capacity, physicochemical stability and controlled release properties
•Novel γ-cyclodextrin-metal–organic frameworks (γ-CD-MOFs) carrier was developed for curcumin delivery system.•Curcumin loaded in γ-CD-MOFs has improved loading capacity, physicochemical stability compared with that loaded in γ-CD.•Curcumin loaded in γ-CD-MOFs can achieve controlled release in simul...
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Published in: | Food chemistry 2021-06, Vol.347, p.128978, Article 128978 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | •Novel γ-cyclodextrin-metal–organic frameworks (γ-CD-MOFs) carrier was developed for curcumin delivery system.•Curcumin loaded in γ-CD-MOFs has improved loading capacity, physicochemical stability compared with that loaded in γ-CD.•Curcumin loaded in γ-CD-MOFs can achieve controlled release in simulated digestion.•Cur : γ-CD-MOFs mass ratio of 2:3 (Cur-CD-MOFs/3) was suggested for further research and industrialization.
A safe and biodegradable γ-cyclodextrin-metal–organic-frameworks (γ-CD-MOFs) was successfully synthesized by using an improved hydrothermal method. In this study, curcumin (Cur) was chosen for testing the encapsulation stability and release performance of γ-CD-MOFs. Results of the crystal structure measurement indicated that the encapsulated curcumin within γ-CD-MOFs via van der Waals forces, hydrophobic interactions and hydrogen bonding was failed to disturb the inherent microtopography and crystallinity of γ-CD-MOFs. Compared to individual γ-CD, the γ-CD-MOFs exhibited improved loading capacity, physicochemical stability as well as controlled-release property in simulated digestion, and hence can be regarded as effective carriers for curcumin. Curcumin-loaded γ-CD-MOFs with a Cur : γ-CD-MOFs mass ratio of 2:3 (Cur-CD-MOFs/3), which showed the highest encapsulation efficiency (67.31 ± 2.25%), improved physicochemical stability and controlled-release performance, was selected for further research and industrialization. Our results demonstrate that γ-CD-MOFs can be regarded as a promising novel carrier for the delivery of curcumin or other hydrophobic nutraceuticals. |
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ISSN: | 0308-8146 1873-7072 |
DOI: | 10.1016/j.foodchem.2020.128978 |