Novel γ-cyclodextrin-metal–organic frameworks for encapsulation of curcumin with improved loading capacity, physicochemical stability and controlled release properties

• Published in: Food chemistry 2021-06, Vol.347, p.128978, Article 128978
• Main Authors: Chen, Yulu, Tai, Kedong, Ma, Peihua, Su, Jiaqi, Dong, Wenxia, Gao, Yanxiang, Mao, Like, Liu, Jinfang, Yuan, Fang
• Format: Article
• Language: English
• Subjects: CD-MOFs; Controlled release; Curcumin; Curcumin - chemistry; Curcumin - metabolism; Drug Carriers - chemistry; Drug Liberation; Drug Stability; gamma-Cyclodextrins - chemistry; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Metal-Organic Frameworks - chemistry; Stability; Temperature; γ-Cyclodextrin
• ISSN: 0308-8146; 1873-7072
• DOI: 10.1016/j.foodchem.2020.128978

•Novel γ-cyclodextrin-metal–organic frameworks (γ-CD-MOFs) carrier was developed for curcumin delivery system.•Curcumin loaded in γ-CD-MOFs has improved loading capacity, physicochemical stability compared with that loaded in γ-CD.•Curcumin loaded in γ-CD-MOFs can achieve controlled release in simulated digestion.•Cur : γ-CD-MOFs mass ratio of 2:3 (Cur-CD-MOFs/3) was suggested for further research and industrialization. A safe and biodegradable γ-cyclodextrin-metal–organic-frameworks (γ-CD-MOFs) was successfully synthesized by using an improved hydrothermal method. In this study, curcumin (Cur) was chosen for testing the encapsulation stability and release performance of γ-CD-MOFs. Results of the crystal structure measurement indicated that the encapsulated curcumin within γ-CD-MOFs via van der Waals forces, hydrophobic interactions and hydrogen bonding was failed to disturb the inherent microtopography and crystallinity of γ-CD-MOFs. Compared to individual γ-CD, the γ-CD-MOFs exhibited improved loading capacity, physicochemical stability as well as controlled-release property in simulated digestion, and hence can be regarded as effective carriers for curcumin. Curcumin-loaded γ-CD-MOFs with a Cur : γ-CD-MOFs mass ratio of 2:3 (Cur-CD-MOFs/3), which showed the highest encapsulation efficiency (67.31 ± 2.25%), improved physicochemical stability and controlled-release performance, was selected for further research and industrialization. Our results demonstrate that γ-CD-MOFs can be regarded as a promising novel carrier for the delivery of curcumin or other hydrophobic nutraceuticals.