Inhibition of multidrug-resistant foodborne Staphylococcus aureus biofilms by a natural terpenoid (+)-nootkatone and related molecular mechanism

Staphylococcus aureus, a foodborne pathogen, poses serious problems to the food industries owing to biofilm formation, and over 25% of the foodborne illnesses in China have been attributed to S. aureus only. Phytochemicals are widely used as anti-biofilm agents with promising efficacy, and most of t...

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Bibliographic Details
Published in:Food control 2020-06, Vol.112, p.107154, Article 107154
Main Authors: Farha, Arakkaveettil Kabeer, Yang, Qiong-Qiong, Kim, Gowoon, Zhang, Dan, Mavumengwana, Vuyo, Habimana, Olivier, Li, Hua-Bin, Corke, Harold, Gan, Ren-You
Format: Article
Language:English
Subjects:
(+)-Nootkatone
Biofilm
Mechanisms
Multidrug resistance
Phytochemical
Staphylococcus aureus
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Summary:Staphylococcus aureus, a foodborne pathogen, poses serious problems to the food industries owing to biofilm formation, and over 25% of the foodborne illnesses in China have been attributed to S. aureus only. Phytochemicals are widely used as anti-biofilm agents with promising efficacy, and most of them are widely available and safe. This study reported the anti-biofilm efficacy of (+)-nootkatone, a sesquiterpene ketone found in a common fruit grapefruit, against multidrug-resistant S. aureus and its potential molecular mechanism. (+)-Nootkatone exhibited bacteriostatic and bactericidal effects at 200 and 400 μg/mL, respectively, against S. aureus SJTUF 20758 and S. aureus ATCC 25923. Crystal violet staining indicated that (+)-nootkatone inhibited S. aureus biofilm formation (p 
ISSN:0956-7135
1873-7129
DOI:10.1016/j.foodcont.2020.107154