Effect of in vitro digestion of yerba mate (Ilex paraguariensis A. St. Hil.) extract on the cellular antioxidant activity, antiproliferative activity and cytotoxicity toward HepG2 cells

The aim of this study was to evaluate the influence of the in vitro gastrointestinal digestion of yerba mate extract on the cellular antioxidant activity (CAA) and cytotoxic and antiproliferative action toward HepG2 cells. The total reducing substances, isolated phenolic acids, total flavonoids and...

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Bibliographic Details
Published in:Food research international 2015-11, Vol.77, p.257-263
Main Authors: Boaventura, Brunna Cristina Bremer, Amboni, Renata Dias de Mello Castanho, da Silva, Edson Luiz, Prudencio, Elane Schwinden, Di Pietro, Patricia Faria, Malta, Luciana Gomes, Polinati, Renata Madureira, Liu, Rui Hai
Format: Article
Language:English
Subjects:
Antiproliferation
Cellular antioxidant activity
Cytotoxicity
Ilex paraguariensis
In vitro digestion
Phenolics
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Summary:The aim of this study was to evaluate the influence of the in vitro gastrointestinal digestion of yerba mate extract on the cellular antioxidant activity (CAA) and cytotoxic and antiproliferative action toward HepG2 cells. The total reducing substances, isolated phenolic acids, total flavonoids and total antioxidant activity of the yerba mate extract decreased significantly after in vitro digestion. The digested extract promoted lower CAA and inhibition of HepG2 cell proliferation when compared to the non-digested extract (P
ISSN:0963-9969
1873-7145
DOI:10.1016/j.foodres.2015.05.004