Origami chips: Development and validation of a paper-based Lab-on-a-Chip device for the rapid and cost-effective detection of 4-methylmethcathinone (mephedrone) and its metabolite, 4-methylephedrine in urine

•Mephedrone, a synthetic cathinone, is a widely used new psychoactive substance.•We present a Lab-on-a-Chip to detect mephedrone at clinically relevant levels.•Cross-reactivity with common adulterants, stability and reproducibility were examined.•Using a Lab-on-a-Chip enables rapid (

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Bibliographic Details
Published in:Forensic chemistry 2021-03, Vol.22, p.100293, Article 100293
Main Authors: McNeill, Lauren, Pearson, Catherine, Megson, David, Norrey, John, Watson, Danielle, Ashworth, David, Linton, Patricia E., Sutcliffe, Oliver B., Shaw, Kirsty J.
Format: Article
Language:English
Subjects:
Detection
Mephedrone
Microfluidics
NPS
Urine
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Description
Summary:•Mephedrone, a synthetic cathinone, is a widely used new psychoactive substance.•We present a Lab-on-a-Chip to detect mephedrone at clinically relevant levels.•Cross-reactivity with common adulterants, stability and reproducibility were examined.•Using a Lab-on-a-Chip enables rapid (
ISSN:2468-1709
2468-1709
DOI:10.1016/j.forc.2020.100293