Parenteral nutrition and oxidant stress in the newborn: A narrative review

There is strong evidence that oxidant molecules from various sources contaminate solutions of parenteral nutrition following interactions between the mixture of nutrients and some of the environmental conditions encountered in clinical practice. The continuous infusion of these organic and nonorgani...

Full description

Saved in:
Bibliographic Details
Published in:Free radical biology & medicine 2019-10, Vol.142, p.155-167
Main Authors: Lavoie, Jean-Claude, Chessex, Philippe
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:There is strong evidence that oxidant molecules from various sources contaminate solutions of parenteral nutrition following interactions between the mixture of nutrients and some of the environmental conditions encountered in clinical practice. The continuous infusion of these organic and nonorganic peroxides provided us with a unique opportunity to study in cells, in vascular and animal models, the mechanisms involved in the deleterious reactions of oxidation in premature infants. Potential clinical impacts of peroxides infused with TPN include: a redox imbalance, vasoactive responses, thrombosis of intravenous catheters, TPN-related hepatobiliary complications, bronchopulmonary dysplasia and mortality. This is a narrative review of published data. [Display omitted] •Narrative review of parenteral nutrition associated oxidant stress.•Biochemical markers of radical and non radical oxidant stress.•Experimental and clinical models developed for proof of concenpt•Non invasive antioxidant strategies: photoprotection.•Development: glautathione admixture to TPN.
ISSN:0891-5849
1873-4596
DOI:10.1016/j.freeradbiomed.2019.02.020