A DYS438 null allele observed in two generations of a large family

Typing of Y-chromosomal STR loci using the AmpFISTR ® Yfiler kit showed a DNA profile lacking the DYS438 allele in an Austrian Caucasoid brother pair. Buccal swabs were collected from additional males of two generations and different branches of the family. All family members investigated did not sh...

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Bibliographic Details
Published in:Forensic science international. Genetics supplement series 2008-08, Vol.1 (1), p.206-207
Main Authors: Glock, B., Dauber, E.M., Parson, W., Schwartz-Jungl, E.M., Mayr, W.R.
Format: Article
Language:English
Subjects:
DYS438
Null allele
STR
Y chromosome
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Summary:Typing of Y-chromosomal STR loci using the AmpFISTR ® Yfiler kit showed a DNA profile lacking the DYS438 allele in an Austrian Caucasoid brother pair. Buccal swabs were collected from additional males of two generations and different branches of the family. All family members investigated did not show a DYS438 allele in their Yfiler profile. Using the Powerplex ® Y system an allele with dramatically reduced peak height was amplified. Subsequent sequencing of the DYS438 locus exhibited a transition upstream of the repetitive region.
ISSN:1875-1768
1875-175X
DOI:10.1016/j.fsigss.2007.10.154