A paternal mutation in the Penta D STR locus

In the field of paternity testing, inconsistencies between tested individuals can point to non-paternity or the presence of a mutation or mutations. We report on a case where one inconsistency was observed between a putative father and his daughter following routine STR typing using Powerplex-16 (Pr...

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Bibliographic Details
Published in:Forensic science international. Genetics supplement series 2009-12, Vol.2 (1), p.221-223
Main Authors: Thacker, C.R., Musgrave-Brown, E., Ballard, D., Syndercombe-Court, Y.D.
Format: Article
Language:English
Subjects:
Mutation
Paternity testing
Penta D
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Summary:In the field of paternity testing, inconsistencies between tested individuals can point to non-paternity or the presence of a mutation or mutations. We report on a case where one inconsistency was observed between a putative father and his daughter following routine STR typing using Powerplex-16 (Promega) and SGM Plus (Applied Biosystems). A three-step mutation was detected in the Penta D STR locus. A paternity index of 99.9999% was obtained. Following the additional analysis of over 50 different independent tests and the testing of other family members, no further inconsistencies were detected.
ISSN:1875-1768
1875-175X
DOI:10.1016/j.fsigss.2009.10.001