Microhaplotype loci are a powerful new type of forensic marker

Modern sequencing technology makes it possible to genotype polymorphisms with high throughput and high multiplexing. We have searched for and identified many loci with 2 or more SNPs within the expanse of a 200bp single sequence run and show that when linkage disequilibrium is not complete these loc...

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Bibliographic Details
Published in:Forensic science international. Genetics supplement series 2013, Vol.4 (1), p.e123-e124
Main Authors: Kidd, K.K., Pakstis, A.J., Speed, W.C., Lagace, R., Chang, J., Wootton, S., Ihuegbu, N.
Format: Article
Language:English
Subjects:
Ancestry
Haplotype
Polymorphism
Sequencing
SNP
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Summary:Modern sequencing technology makes it possible to genotype polymorphisms with high throughput and high multiplexing. We have searched for and identified many loci with 2 or more SNPs within the expanse of a 200bp single sequence run and show that when linkage disequilibrium is not complete these loci have multiple alleles detected as phase-known haplotypes. These microhaplotype loci (microhaps) are a powerful tool for individual identification, ancestry inference, and determining family/clan relationships.
ISSN:1875-1768
1875-175X
DOI:10.1016/j.fsigss.2013.10.063