Effect of linkage on sibship determination based on likelihood ratio

In forensic genetics, increasing the number of short tandem repeat (STR) loci is an efficient strategy to achieve a high likelihood ratio (LR) for sibship determination. However, as the number of loci increases, the effect of linkage among the loci may become more pronounced. Hence, we evaluated the...

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Bibliographic Details
Published in:Forensic science international. Genetics supplement series 2015-12, Vol.5, p.e126-e127
Main Authors: Morimoto, Chie, Manabe, Sho, Kawai, Chihiro, Fujimoto, Shuntaro, Tamaki, Keiji
Format: Article
Language:English
Subjects:
Kinship analysis
Likelihood ratio
Linkage
Sibship analysis
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Summary:In forensic genetics, increasing the number of short tandem repeat (STR) loci is an efficient strategy to achieve a high likelihood ratio (LR) for sibship determination. However, as the number of loci increases, the effect of linkage among the loci may become more pronounced. Hence, we evaluated the effect of linkage on sibship determination when analyzing multiple loci including linked loci. We investigated LR value variation in two linked loci by changing the recombination rate and allele frequencies. We then compared LR values with values calculated without considering linkage, using computationally generated genotypes of sibling pairs. These results suggested that the effect of linkage on LR values in sibship determination is affected by the identity by state of the loci, allele frequencies, and number of loci. Therefore, linkage must be considered to calculate rigorous LR values.
ISSN:1875-1768
1875-175X
DOI:10.1016/j.fsigss.2015.09.051