Characterization and prevalence of extraintestinal manifestations in a cohort of patients with inflammatory intestinal disease in Medellin, Colombia

• Published in: Gastroenterología y Hepatología (English Edition) 2021-06, Vol.44 (6), p.398-404
• Main Authors: Juliao-Baños, Fabián, Arrubla, Mateo, Osorio, Laura, Camargo, Joselyn, Londoño, Juliana, Cáceres, Camilo, Carvajal, Jhon, Mosquera-Klinger, Gabriel, Donado, Jorge
• Format: Article
• Language: English
• Subjects: Colitis ulcerativa; Crohn's disease; Enfermedad de Crohn; Extraintestinal manifestations; Manifestaciones extraintestinales; Ulcerative colitis
• ISSN: 2444-3824; 2444-3824
• DOI: 10.1016/j.gastre.2020.07.015

Extraintestinal manifestations (EIMs) are frequent in patients with inflammatory bowel disease (IBD). Our objective is to characterise and determine the prevalence of MEIs in our cohort of patients with IBD. A retrospective study was carried out in adult patients with IBD at the Pablo Tobón Uribe Hospital in Medellín. Colombia. Articular MEIs, primary sclerosing cholangitis (PSC), both ophthalmological and dermatological, were considered. Absolute and relative frequencies were used. The Chi square test of independence was used to compare 2 proportions and the odds ratio (OR) was estimated. Our registry has 759 patients with IBD, 544 present UC (71.6%), 200 CD (26.3%) and 15 unclassifiable IBD (1.9%); 177 patients with IBD (23.3%) presented EIMs, 123 of 544 (22.6%) with UC and 53 of 200 (26.5%) with CD (OR: 0.81, 95% CI: 0.55–1.17, p=0.31). Regarding the type of EIMs, the articular ones were the most frequent (13.5%), more in CD than in UC (20.0 vs. 11.3%, OR 1.94, 95% CI: 1.25–3.00, p=0.0037). Patients with IBD and EIMs used more antibodies against tumour necrosis factor (anti-TNFs), compared to those without EIMs (43.5 vs. 18.5%, OR 3.38, 95% CI: 2.31–4.90, p=0.0001). The prevalence of EIMs in our cohort is high (23.3%) and the most frequent type is joint. Anti-TNFs are most used when IBD and EIMs coexist. Our study provides valuable information on the association of EIMs and IBD in Latin America. Las manifestaciones extraintestinales (MEI) son frecuentes en pacientes con enfermedad inflamatoria intestinal (EII). Nuestro objetivo es caracterizar y determinar la prevalencia de MEI en nuestra cohorte de pacientes con EII. Se realizó un estudio retrospectivo en pacientes adultos con EII del Hospital Pablo Tobón Uribe en Medellín (Colombia). Se consideraron MEI articulares, colangitis esclerosante primaria (CEP), oftalmológicas y dermatológicas. Se emplearon frecuencias absolutas y relativas. Para comparar 2proporciones se utilizó la prueba χ2 de independencia y se estimó el odds ratio (OR). Nuestro registro cuenta con 759 pacientes con EII, 544 presentaban CU (71,6%), 200 EC (26,3%) y 15 EII no clasificable (1,9%). Del total, 177 pacientes con EII (23,3%) presentaron MEI, 123 de 544 (22,6%) con CU y 53 de 200 (26,5%) con EC (OR: 0,81; IC 95%: 0,55-1,17; p=0,31). En cuanto al tipo de MEI, las articulares fueron las más frecuentes (13,5%), más en EC que en CU (20,0 vs. 11,3%; OR 1,94; IC 95%: 1,25-3,00; p=0,0037). Los pacientes con EII y MEI utilizaron más ant