Epigenetic regulation of nuclear receptors: Implications for endocrine-related diseases and therapeutic strategies

The expression and function of the receptor are controlled by epigenetic changes, such as DNA methylation, histone modification, and noncoding RNAs. These modifications play a pivotal role in receptor activity and can lead to or exacerbate endocrine-related diseases. This review examines the epigene...

Full description

Saved in:
Bibliographic Details
Published in:Genes & diseases 2024-12, p.101481, Article 101481
Main Authors: Song, Yixin, Zhang, Kexin, Zhang, Jingwen, Li, Qinying, Huang, Na, Ma, Yujie, Hou, Ningning, Han, Fang, Kan, Chengxia, Sun, Xiaodong
Format: Article
Language:English
Subjects:
Androgen receptor
Breast cancer
DNA methylation
Epigenetic modulation
Estrogen receptor
Histone modification
Nuclear receptor
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The expression and function of the receptor are controlled by epigenetic changes, such as DNA methylation, histone modification, and noncoding RNAs. These modifications play a pivotal role in receptor activity and can lead to or exacerbate endocrine-related diseases. This review examines the epigenetic alterations of nuclear receptors and their significant impact on conditions such as diabetes, thyroid disorders, and endocrine-related tumors. It highlights current therapies targeting these epigenetic mechanisms, including gene editing, epigenetic drugs, and various other therapeutic approaches. This review offers fresh insight into the mechanisms of endocrine-associated disorders, highlighting the latest progress in the development of novel epigenetic therapies that can be used to address receptor–endocrine interactions.
ISSN:2352-3042
2352-3042
DOI:10.1016/j.gendis.2024.101481