The role of GSTM1, GSTT1, GSTP1, and OGG1 polymorphisms in type 2 diabetes mellitus risk: A case–control study in a Turkish population

The aim of the present study was to investigate the role of some polymorphisms in GSTs (GSTM1, GSTT1 and GSTP1) which are very important protective mechanisms against oxidative stress and in OGG1 gene which is important in DNA repair, against the risk of type 2 diabetes mellitus (T2DM). 127 T2DM and...

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Bibliographic Details
Published in:Gene 2012-08, Vol.505 (1), p.121-127
Main Authors: Gönül, Nüvit, Kadioglu, Ela, Kocabaş, Neslihan Aygün, Özkaya, Mesut, Karakaya, Ali Esat, Karahalil, Bensu
Format: Article
Language:English
Subjects:
Adult
Aged
Case-Control Studies
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - genetics
DNA Glycosylases - genetics
Female
Genotype
Glutathione S-Transferase pi - genetics
Glutathione Transferase - genetics
GSTM1
GSTP1
GSTT1
Humans
Male
Middle Aged
OGG1 Ser326Cys
Oxidative stress
Polymorphism, Genetic
Risk Factors
Turkey - epidemiology
Type 2 diabetes mellitus
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Summary:The aim of the present study was to investigate the role of some polymorphisms in GSTs (GSTM1, GSTT1 and GSTP1) which are very important protective mechanisms against oxidative stress and in OGG1 gene which is important in DNA repair, against the risk of type 2 diabetes mellitus (T2DM). 127 T2DM and 127 control subjects were included in the study. DNA was extracted from whole blood. Analyses of GSTM1 and GSTT1 gene polymorphisms were performed by allele specific PCR and those of GSTP1 Ile105Val and OGG1 Ser326Cys by PCR‐RFLP. Our data showed that GSTM1 null genotype frequency had a 2–6 times statistically significant increase in a patient group (OR=3.841, 95% CI=2.280–6.469, p
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2012.05.025