Roles of highly expressed PAICS in lung adenocarcinoma

Phosphoribosylaminoimidazole carboxylase (PAICS), a de novo purine metabolic enzyme, has been identified as an oncogene in several tumor types, including breast cancer and prostate cancer. However, the role of PAICS in human lung adenocarcinoma (LADC) requires further study. In this research, the ef...

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Bibliographic Details
Published in:Gene 2019-04, Vol.692, p.1-8
Main Authors: Zhou, Shuyi, Yan, Yuanliang, Chen, Xi, Wang, Xiang, Zeng, Shuangshuang, Qian, Long, Wei, Jie, Yang, Xue, Zhou, Yangying, Gong, Zhicheng, Xu, Zhijie
Format: Article
Language:English
Subjects:
Lung adenocarcinoma
Methylation
PAICS
Therapeutic target
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Summary:Phosphoribosylaminoimidazole carboxylase (PAICS), a de novo purine metabolic enzyme, has been identified as an oncogene in several tumor types, including breast cancer and prostate cancer. However, the role of PAICS in human lung adenocarcinoma (LADC) requires further study. In this research, the effects of PAICS on the occurrence and prognosis of LADC were evaluated using integrative bioinformatics analyses. By employing the bioinformatics analyses of several public databases, PAICS, which is overexpressed in the LADC tissues, was identified as a potential tumor-promoting gene in LADC biology. Several relevant clinical studies indicated that the upregulation of PAICS was statistically correlated with a shorter overall survival time. Moreover, the carcinogenic function of PAICS in LADC was validated by the further protein-protein interactions (PPI) and biological process annotation analysis. Mechanistically, we found that the PAICS methylation level was significantly lower in the LADC tissues compared to the normal lung tissues. Furthermore, using the MEXPRESS web tool, we predicted 15 possible DNA methylation sites in the nucleotide sequences of PAICS, which could explain the alteration in the PAICS expression levels in LADC. Our work demonstrates that high levels of PAICS are found in LADC and that this gene may be a potential therapeutic target for this subset of lung cancers. Determining the detailed roles of PAICS in LADC biology may provide useful information for further investigations. •PAICS is overexpressed in the LADC tissues and cells•Upregulation of PAICS was statistically correlated with a shorter OS time in LADC patients•PAICS methylation level was significantly lower in the LADC tissues
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2018.12.064