A genetic analysis identifies haplotype at adiponectin locus: Association with the metabolic health and obesity phenotypes

•Genetic variants in ADIPOQ explained the heterogeneity among obesity phenotypes.•Adiponectin levels differed among genotypes for rs2241766 and rs1501299 variants.•G allele of rs2241766 was negatively associated with metabolically unhealth obese.•T allele of rs1501299 exhibited reduced odds for meta...

Full description

Saved in:
Bibliographic Details
Published in:Gene 2021-06, Vol.784, p.145593, Article 145593
Main Authors: Zhu, Xiaoyue, Hu, Jingyao, Yang, Man, Guo, Haijian, Ji, Dakang, Li, Yimeng, Wang, Wei, Xue, Chenghao, Wang, Ning, Zhang, Xiaomeng, Hu, Xueqing, Liu, Yuxiang, Sun, Kaicheng, Sun, Zilin, Wang, Bei
Format: Article
Language:English
Subjects:
Adiponectin - genetics
ADIPOQ
Adult
Asian Continental Ancestry Group - genetics
Body Mass Index
Case-Control Studies
China - ethnology
Female
Genetic Association Studies
Genetic Predisposition to Disease
Haplotypes
Humans
Logistic Models
Male
Metabolic Syndrome - genetics
Metabolically healthy
Middle Aged
Obesity - genetics
Obesity phenotypes
Phenotype
Polymorphism
Polymorphism, Single Nucleotide
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Genetic variants in ADIPOQ explained the heterogeneity among obesity phenotypes.•Adiponectin levels differed among genotypes for rs2241766 and rs1501299 variants.•G allele of rs2241766 was negatively associated with metabolically unhealth obese.•T allele of rs1501299 exhibited reduced odds for metabolically health obese.•Correlation existed between rs1501299 and metabolically unhealth normal weight. Obesity and metabolic syndrome frequently co-exist and define obese individuals into different obesity phenotypes, such as metabolically healthy obese (MHO), metabolically unhealthy obese (MUO) and metabolically unhealthy normal weight (MUNW). Growing evidence suggests that genetic predisposition and environmental factors can explain the heterogeneity among these phenotypes. We conducted a case-control study including 130 MHO, 251 MUNW, 208 MUO and 336 health controls by genotyping 2 SNPs (rs2241766, rs1501299) in ADIPOQ to investigate possible associations between SNPs in the ADIPOQ gene with susceptibility to three obese phenotypes respectively in Chinese Han population. Unconditional logistic regressions were used to detect the association between ADIPOQ SNPs and MHO/MUNW/MUO risks. Variant G allele of rs2241766 was associated with a reduced odds of MUO (additive model: Adjusted OR = 0.55; 95% CI = 0.40–0.75; P 
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2021.145593