Polymorphism of the IFN-ɣ gene in the Azeri population of Iran

IFN-ɣ is considered as one of the major cytokines in the immune responses against the infections. Various polymorphisms in this gene affect the biological functions, which have the ability to make predisposed individuals to some of the diseases. The aim of this study was investigating of polymorphis...

Full description

Saved in:
Bibliographic Details
Published in:Gene reports 2020-06, Vol.19, p.100596, Article 100596
Main Authors: Asgharzadeh, Mohammad, Fadaee, Manouchehr, Mahdavipoor, Behroz, Sheykhsaran, Elham, Rashedi, Jalil, Pourostadi, Mahya, Asgharzadeh, Vahid, Vegari, Ali, Kafil, Hossein Samadi
Format: Article
Language:English
Subjects:
Genotype
IFN-ɣ
Iranian Azeri population
Single nucleotide polymorphism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:IFN-ɣ is considered as one of the major cytokines in the immune responses against the infections. Various polymorphisms in this gene affect the biological functions, which have the ability to make predisposed individuals to some of the diseases. The aim of this study was investigating of polymorphism of IFN-ɣ gene in Azeri population in the +874 location. Blood samples were collected from 240 healthy and non-relative Azeri population. The determination of IFN-ɣ genotypes was conducted through Allele-specific PCR method after DNA extraction. Thereafter, comparison of the frequency of alleles and IFN-ɣ genotypes with other populations was carried out with q-square test and p-value 
ISSN:2452-0144
2452-0144
DOI:10.1016/j.genrep.2020.100596