Copper oxide nanoparticles induce oxidative stress mediated apoptosis in carp (Cyprinus carpio) larva

Negative effects of metal oxide nanoparticles on the aquatic organisms and ecosystems have recently much considered. Copper oxide nanoparticles are widely used in various industrial, and this problem cause concerns for aquatic organisms. This study aimed to determine the acute toxicity and the effec...

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Bibliographic Details
Published in:Gene reports 2020-06, Vol.19, p.100676, Article 100676
Main Authors: Naeemi, Akram Sadat, Elmi, Fatemeh, Vaezi, Gholamhassan, Ghorbankhah, Maedeh
Format: Article
Language:English
Subjects:
Apoptosis
Cyprinus carpio
Enzymes activity
Histology
Larvae
Nanoparticles
Sublethal concentration
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Summary:Negative effects of metal oxide nanoparticles on the aquatic organisms and ecosystems have recently much considered. Copper oxide nanoparticles are widely used in various industrial, and this problem cause concerns for aquatic organisms. This study aimed to determine the acute toxicity and the effects of copper oxide nanoparticles (CuO NPs) on tissue histology, bioaccumulation, antioxidant enzymes activity and the expression of apoptosis genes of the carp (Cyprinus carpio) larvae. For this purpose, four days old carp larvae after determination of the lethal concentration (LC50-96h), were exposed to 0.1, 0.2, 0.5 and 1 mg/l of CuO nanoparticles and control in three replicates. After seven days, histological studies showed no specific tissue damage at the studied concentrations, but the activities of superoxide dismutase (SOD), glutathione S-transferases (GST) and catalase (CAT) enzymes in all of the treatments, showed a significant increase compared to control (P 
ISSN:2452-0144
2452-0144
DOI:10.1016/j.genrep.2020.100676