Association of interleukin1β, interleukin1 receptor antagonist, interleukin 6 and angiotensin II receptor type I gene polymorphisms with end stage renal disease: A meta-analysis

• Published in: Gene reports 2020-12, Vol.21, p.100856, Article 100856
• Main Authors: Murugan, Divya, Natarajan, Gayathri, Natarajan, Shakthisree, Benita, Sharon, Varghese, Sindhu, Langeswaran, Subbaraj, Gowtham Kumar
• Format: Article
• Language: English
• Subjects: AT1R; End stage renal disease; IL-1RN; IL-1β; IL-6; Meta analysis
• ISSN: 2452-0144; 2452-0144
• DOI: 10.1016/j.genrep.2020.100856

Renal failure has become the most common disease as the incidence constantly increases over the years. The objective of the examination is to analyse the relationship of interleukin-1 beta, interleukin-1 receptor antagonist, interleukin-6, AT1R polymorphisms with end-stage renal failure by meta-analysis. The collection of scientific papers search was executed with electronic information service such as Google Scholar, PubMed, Cochrane and Embase. A total subjects of 6842 controls and 6305 cases data were obtained from twenty-six case-control studies to recognize the association with ESRD in various populations. Based on genetic models (allele contrast, dominant, over dominant, recessive), the odds ratio (OR) value and 95% confidence interval (CI) have been evaluated. Four gene polymorphisms such as IL-1B, IL-1RN, IL-6 and AT1R were studied. The AT1R gene heterogenicity results showed no significant association with ESRD (allele contrast model p = 0.07, recessive model p = 0.06, dominant model p = 0.18, over dominant model p = 0.02). IL-6 results show no significant risk with ESRD excluding over dominant model (allele contrast model p = 0.25, recessive model p = 0.37, dominant model p = 0.15, over dominant model p = 0.51). IL-1B results showed no significant association with ESRD (allele contrast model p = 0.22, recessive model p = 0.34, dominant model p = 0.17, over dominant model p = 0.56). The IL-1RN results shows the significant association with ESRD except recessive and over dominant (allele contrast model p = 0.02, recessive model p = 0.10, dominant model p = 0.001, over dominant model p = 0.53). The meta-analysis results showed no significant association of IL-1β, IL-6 and AT1R with end-stage renal failure. However, IL-1RN dominant model shows a very significant association with the disease. •Meta-analysis was done to evaluate the association between gene polymorphisms such as AT1R (rs5186), IL-1B (rs16944), IL-6 (rs1800795) and IL-1RN (rs2234663) in the risk of end stage renal disease.•A total number of 6305 ESRD patients and 6842 normal healthy controls from 26 articles were identified having an association with end stage renal disease in the various Caucasians and Asians studies.•The results of this meta analysis established that there is no significant relationship between the gene polymorphism such as AT1R (rs5186), IL-1B (rs16944), and IL-6 (rs1800795) with end stage renal disease. Whereas IL-1RN (rs2234663) gene polymorphism showed a strong as