An extensive meta-analysis of the association of MTHFR c.677C > T and c.1298A > C polymorphisms with gliomas

• Published in: Gene reports 2021-06, Vol.23, p.101111, Article 101111
• Main Authors: Idrissi, Hossam Hilal El, Boujmia, Oum kaltoum Ait, Gazzaz, Bouchaïb, Tazzite, Amal, Dehbi, Hind
• Format: Article
• Language: English
• Subjects: C.1298A > C; C.677C > T; Gliomas; Meta-analysis; MTHFR
• ISSN: 2452-0144; 2452-0144
• DOI: 10.1016/j.genrep.2021.101111

Methylenete trahydro folate reductase (MTHFR) is an enzyme that plays a central role in the metabolism of folate. Many polymorphisms of this gene, particularly thec.677C > T and c.1298A > C, have been studied to investigate the association with the risk of gliomas, but their findings are incongruous. In order to explore this association, we performed this meta-analysis. We conducted an extensive literature search using PubMed, Web of Science, and Google Scholar databases for the relevant studies published through 02nd September 2020. A total of 13 control cases were identified and included in this meta-analysis. We found that c.1298A > C polymorphism was significantly associated with an increased risk of gliomas in the heterozygote model[CT vs AA, odds ratio (OR) = 1.35, 95% confidence of interval (CI): 1.15–1.59, p = 0.002], and the recessive model(CC vs CA + AA, OR = 1.28, 95% CI: 1.10–1.49, p = 0.001). Although, no significant association was observed between c.677C > T polymorphism and the risk of gliomas. Taken together, these data strongly suggest that c.1298A > C polymorphism may contribute to gliomas susceptibility.