High diversity of virulent and multidrug-resistant Stenotrophomonas maltophilia in Iraq

Stenotrophomonas maltophilia (S. maltophilia) is an emerging opportunistic nosocomial pathogen causing various infections. The aim of our study was to characterize S. maltophilia isolates regarding phylogenetic typing, virulence factors and multidrug-resistance determinants of S. maltophilia in Iraq...

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Bibliographic Details
Published in:Gene reports 2021-06, Vol.23, p.101124, Article 101124
Main Authors: Saleh, Raed Obaid, Hussen, Bashdar Mahmud, Mubarak, Shaden M.H., Mostafavi, Seyyed Khalil Shokouhi
Format: Article
Language:English
Subjects:
Iraq
Multidrug-resistance
Phylogenetic typing
Stenotrophomonas maltophilia
Virulence factors
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Summary:Stenotrophomonas maltophilia (S. maltophilia) is an emerging opportunistic nosocomial pathogen causing various infections. The aim of our study was to characterize S. maltophilia isolates regarding phylogenetic typing, virulence factors and multidrug-resistance determinants of S. maltophilia in Iraq. A total of 3569 samples were collected from respiratory and septicemia infections. Considering guidelines given by clinical and laboratory standards institute 2018, the susceptibility of isolates was determined. The biofilm formation was performed using microtiter tissue plate (Mtp) assay. Screening of antibiotic resistance and virulence determinants was implemented using polymerase chain reaction (PCR) technique. The pulsed field gel electrophoresis (PFGE) was performed for genetic typing of strains. The age range 55–75 years (61%, p = 0.038) was significantly more affected. Previous hospitalization and antibiotic consumption was determined among 72% (p 
ISSN:2452-0144
2452-0144
DOI:10.1016/j.genrep.2021.101124