Association between miRNAs expression and multiple sclerosis pathogenesis: A novel therapeutic approach

Multiple Sclerosis (MS) is an immune-mediated neurodegenerative disorder that can affect both the nervous and immune systems of the body. The determination of diagnostic, prognostic, and treatment-associated biomarkers has attracted the attention of many researchers. MiRNAs, as non-coding RNAs, play...

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Bibliographic Details
Published in:Gene reports 2022-03, Vol.26, p.101457, Article 101457
Main Authors: Beyrampour-Basmenj, Hanieh, Rahmati, Mohammad, Moghamddam, Mohammad Pourhassan, Kalan, Mohammad Ebrahimi, Alivand, Mohammadreza, Aliyari-Serej, Zeynab, Nastarin, Parastou, Omrani, Mohammadhassan, Khodakarimi, Sina, Ebrahimi-Kalan, Abbas
Format: Article
Language:English
Subjects:
And therapeutic strategies
microRNA
Multiple sclerosis
Nervous system
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Summary:Multiple Sclerosis (MS) is an immune-mediated neurodegenerative disorder that can affect both the nervous and immune systems of the body. The determination of diagnostic, prognostic, and treatment-associated biomarkers has attracted the attention of many researchers. MiRNAs, as non-coding RNAs, play a pivotal role in modifying the autoimmune process of MS in both immune and nerve cells. They have great potential to be developed as diagnostic and therapeutic biomarkers. This review comprehensively summarizes the variably expressed miRNAs in neural cells, and MS patients' biofluids. It has been proven that some dysregulated miRNAs are related to the pathogenesis of the disease, and these miRNAs could be utilized as biomarkers in determining various states of MS and defining effective therapeutic strategies. MiRNA-mediated regulation of nervous system in multiple sclerosis. [Display omitted] •Evidence has demonstrated the vital role of miRNAs in CNS development as important regulators of gene expression in all the phases of neurogenesis.•The importance of miRNAs in neurogenesis, glial cells, and biofluids in MS has been discussed with the aim of assessing their potential as biomarkers for diagnosis and describing novel therapeutic methods in MS treatment.•miRNA-based therapeutic approaches can be used as a replacement of dysregulated miRNA or suppressive of it, with novel methods such as anti-miRs, miRNAs sponges, and target-site blockers.
ISSN:2452-0144
2452-0144
DOI:10.1016/j.genrep.2021.101457