Sub-group analysis of inflammatory cytokines IL-1 and IL-6 in association with lipid profiles of coronary artery disease patients

• Published in: Gene reports 2023-03, Vol.30, p.101748, Article 101748
• Main Authors: Balakrishna, D., Sowjanya, B., Prasad, M., Viswakumar, R.
• Format: Article
• Language: English
• Subjects: Coronary artery disease; IL-1 and IL-6; Lipid profile; Sub-group analysis
• ISSN: 2452-0144; 2452-0144
• DOI: 10.1016/j.genrep.2023.101748

Although possible effects of lipid parameters, and several important genetic factors, and cytokines on the development of coronary artery disease (CAD) have been demonstrated, there is still debate about how the lipid profile affects the sub-group of patients in a specific population. This study aimed to evaluate age- and gender-based effect of lipid profile in correlation with their IL-1 and IL-6 cytokine levels in South Indian population. Angiographically confirmed 150 CAD patients' with or without hypertension and 150 healthy control individuals of both the genders between 18 and 70 years of age were enrolled. Quantitative estimation of IL-1 and IL-6 protein in each serum sample was evaluated using ELISA. The plasma concentrations of cholesterol, HDL, LDL, VLDL and triglycerides were determined using different biochemical tests. Correlation was established between cytokines and lipid profile of patients in different sub-groups using Pearson's linear regression analysis. Sub-group analysis showed VLDL and triglyceride levels as significant risk factors for CAD, especially in women patients. Older men (>40 years) and younger women (