The roles of miR-383 as a diagnostic and prognostic biomarker in human cancers

• Published in: Gene reports 2024-09, Vol.36, p.101966, Article 101966
• Main Authors: Panahizadeh, Reza, Vatankhah, Mohammadamin, Gholizadeh, Pourya, Faghfuri, Elnaz, Pahlavan, Yasamin, Soozangar, Narges, Nejati-Koshki, Kazem
• Format: Article
• Language: English
• Subjects: Cancer; MicroRNA expression; miRNA-383; Signaling pathway
• ISSN: 2452-0144; 2452-0144
• DOI: 10.1016/j.genrep.2024.101966

Emerging evidence indicates that Long non-coding RNAs (LncRNAs) and microRNAs (miRNAs) play crucial roles in the biology of cancerous cells. MicroRNAs are small non-coding RNAs, which play essential roles in the different cellular processes of various cancers. The miR-383 was initially found as a tumor suppressor and prognostic marker in different human cancers. The regulation of miR-383 and its target gene expression could be helpful in the prevention of tumorigenesis, improving cancer prognosis, and enhancing 5-year survival of patients with cancer. Current study suggests that miR-383 expression is implicated in the pathogenesis and in predicting molecular progression, cellular proliferation, and patient prognosis in various carcinomas. The up-regulation of miR-383 can reduce the prognosis of the cancers. MiR-383 exerts its tumor-suppressive effects in vitro by targeting specific proteins and molecules, which regulate the signaling pathways of cancer cells. Therefore, we aimed to discuss the different functions of miR-383 in various cancers and highlight its role in the signaling pathways regulation, that are involved in cancers. •miR-383 is implicated in the pathogenesis.•miR-383 reduces cancer prognosis.•miR-383 enhances cell death and suppresses the development of cancer.•miR-383 could be a non-invasive biomarker for cancer screening.