Role of 1,25-dihydroxy vitamin D3 pathway in chronic urticaria: Findings from a hospital-based case-control study

Previous research has linked dysregulation of the vitamin D pathway to skin diseases. In this study, we sought to explore the genetic variations in the vitamin D receptor (VDR) and vitamin D-binding protein (VDBP), alongside the estimation of serum vitamin D and VDBP levels in Chronic Urticaria (CU)...

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Bibliographic Details
Published in:Gene reports 2025-03, Vol.38, p.102093, Article 102093
Main Authors: Kawoosa, Fizalah, Shafi, Tabasum, Rasool, Roohi, Nazir, Shazia, Kounsar, Nusrat
Format: Article
Language:English
Subjects:
Chronic Urticaria
rs1544410
rs2228570
rs7041
Vitamin D binding protein
Vitamin D levels
Vitamin D receptor
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Summary:Previous research has linked dysregulation of the vitamin D pathway to skin diseases. In this study, we sought to explore the genetic variations in the vitamin D receptor (VDR) and vitamin D-binding protein (VDBP), alongside the estimation of serum vitamin D and VDBP levels in Chronic Urticaria (CU) patients. Blood samples were obtained from all participants (n = 200) to assess serum vitamin D, VDBP, and total IgE levels using enzyme-linked immunosorbent assay (ELISA). Additionally, DNA was extracted from the blood samples for analysis of VDR (rs1544410, rs2228570) and VDBP (rs7041) polymorphisms using polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP). CU patients exhibited elevated levels of total IgE (208.29 ± 151.293 vs. 125.91 ± 73.13 IU/ml) and VDBP (570.59 ± 158.74 vs. 314.408 ± 140.31 μg/ml) (p-value 
ISSN:2452-0144
2452-0144
DOI:10.1016/j.genrep.2024.102093