Emerging roles of peroxisome proliferator-activated receptors in the pituitary gland in female reproduction

Abstract Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors that mediate numerous crucial physiological processes, including glucose and lipid metabolism, energy homeostasis, inflammation, cell proliferation, and differentiation. Therefore, targeting of PPARs...

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Bibliographic Details
Published in:Biomarkers and genomic medicine 2013-03, Vol.5 (1), p.1-11
Main Authors: Shiue, Yow-Ling, Chen, Lih-Ren, Tsai, Chia-Jung, Yeh, Chung-Yu, Huang, Chiang-Ting
Format: Article
Language:English
Subjects:
Advanced Basic Science
female reproduction
Medical Education
peroxisome proliferator-activated receptor (PPAR)
pituitary gland
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Summary:Abstract Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors that mediate numerous crucial physiological processes, including glucose and lipid metabolism, energy homeostasis, inflammation, cell proliferation, and differentiation. Therefore, targeting of PPARs for metabolic diseases, cardiovascular diseases, polycystic ovary syndrome, and cancer therapies is intensive. Over the last decade, studies on PPARs have shed light on their functional roles in the female reproductive system, including the hypothalamus–pituitary–gonad axis, placental development, and maternal-infant interactions. In this review we summarize PPAR genomic organization, molecular functions, and expression patterns, as well as insights from knockout mice and PPAR involvement in biological processes, with a focus on their novel role in the pituitary gland in female reproduction.
ISSN:2214-0247
2214-0255
DOI:10.1016/j.gmbhs.2013.04.008