Improvement of chlorination and sterilization of pathogenic bacteria by natural products

•Cinnamaldehyde combined with chlorine disinfection can increase the inactivation of ARB.•The process of biofilm formation is inhibited by the combination strategy.•Disruption of mature biofilms further leads to inactivation of ARB.•Increased cell membrane permeability and enhanced ROS are possible...

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Bibliographic Details
Published in:Journal of hazardous materials advances 2023-05, Vol.10, p.100318, Article 100318
Main Authors: Guo, Jingjing, Wang, Bingjie, Qiu, Xiao, Ren, Shaojie, Wang, Yunkun
Format: Article
Language:English
Subjects:
Antibiotic resistance
Chlorination disinfection
Cinnamaldehyde
Combined sterilization strategy
Pathogenic bacteria
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Summary:•Cinnamaldehyde combined with chlorine disinfection can increase the inactivation of ARB.•The process of biofilm formation is inhibited by the combination strategy.•Disruption of mature biofilms further leads to inactivation of ARB.•Increased cell membrane permeability and enhanced ROS are possible inactivation mechanisms. There are many highly resistant pathogenic bacteria in the environment that cannot be removed by conventional chlorination disinfection. This study demonstrated a combined sterilization strategy for combating the extension of pathogenic bacteria by enhancing the bactericidal ability of sodium hypochlorite at subinhibitory concentrations with the utilization of the natural antimicrobial molecule cinnamaldehyde. The results indicated that treatment of cinnamaldehyde enhances the effect of chlorination disinfection, leading to an increase in concentration-dependent inactivation efficiency from 33.5 to 86.1%. Our results also proved that the combined sterilization strategy showed an inhibitory and destructive effect on the hazardous biofilm formed by Pseudomonas aeruginosa. Additionally, the cell membrane permeability and reactive oxygen species (ROS) levels were 1.8-fold and 2.3-fold increased compared with the controls, respectively, which revealed the synergistic effect and hypothetical mechanisms of natural antimicrobial products treatment to chlorination disinfection. This study provides further research for the control of drug-resistant bacteria in water treatment systems and contributes to combating the growing threat of antibiotic resistance. [Display omitted]
ISSN:2772-4166
2772-4166
DOI:10.1016/j.hazadv.2023.100318