Comparison of the effect of topical use of Nigella Sativa oil and diclofenac gel on osteoarthritis pain in older people: A randomized, double-blind, clinical trial

Osteoarthritis is one of the most common diseases in the elderly. Herbal remedies create pain relief with appropriate clinical effects and less toxicity. We aimed to investigate the effect of Nigella sativa oil compared with diclofenac gel on the reduction of osteoarthritis pain in older people. Thi...

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Bibliographic Details
Published in:Journal of herbal medicine 2019-06, Vol.16, p.100259, Article 100259
Main Authors: Azizi, Fatemeh, Ghorat, Fereshteh, Hassan Rakhshani, Mohammad, Rad, Mostafa
Format: Article
Language:English
Subjects:
Diclofenac gel
Knee joint
Nigella sativa oil
Older people
Osteoarthritis
Pain
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Summary:Osteoarthritis is one of the most common diseases in the elderly. Herbal remedies create pain relief with appropriate clinical effects and less toxicity. We aimed to investigate the effect of Nigella sativa oil compared with diclofenac gel on the reduction of osteoarthritis pain in older people. This was a double-blind clinical trial. Samples were 52 men and women aged 60–80 years. They were selected using a convenience method, that were randomly assigned into Nigella sativa oil and diclofenac gel groups. The topical application of Nigella sativa oil and diclofenac gel was performed twice a day in the morning and night for 21 days. The Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire was used for data collection about pain before the use of drugs, in the tenth day and the twenty-first day of the intervention. Paired t-test showed that both interventions improved pain in the subjects (P 
ISSN:2210-8033
DOI:10.1016/j.hermed.2019.100259