The effect of Aqueous, Ethanolic extracts of Rheum ribeson insulin sensitivity, inflammation, oxidative stress in patients with type 2 diabetes mellitus: A Randomized, Double-Blind, Placebo-Controlled Trial

• Published in: Journal of herbal medicine 2020-12, Vol.24, p.100389, Article 100389
• Main Authors: Ghafouri, Atie, hajiluian, Ghazaleh, karegar, Sahar Jafari, Hosseini, Sharieh, Shidfar, Shahrzad, Kamalinejad, Mohammad, AghaHosseini, Fatemeh, Heydari, Iraj, Shidfar, Farzad
• Format: Article
• Language: English
• Subjects: aqueous extract; ethanolic extract; Rheumribes and diabetes mellitus
• ISSN: 2210-8033
• DOI: 10.1016/j.hermed.2020.100389

•According to these findings, we observed a significant reduction in serum levels of insulin (AG; P = 0.003, EG; P = 0.001) and HOMA-IR (AG; P = 0.01, EG; P = 0.00) and HOMA-B (AG; P = 0.00, EG; P = 0.00) indices in the AE and EE intervention group, without no significant changes inFBS. There was also a significant reduction in serum levels of apoB (AG; P = 0.00, EG; P = 0.03) and apoB/apoA-I (AG; P = 0.01, EG; P = 0.04) ratio in both AG and EG; However, intervention in both AG and EG has no effect on apoA-I (P = 0.06). It seems that the ethanolic extract as well as aqueous extract of Rheum ribes is effective in diabetic patients. Type 2 diabetes mellitus, one of the most common chronic metabolic disorders, occurs when the body is unable to utilize insulin effectively. Hyperglycemia, one of the most common characteristics of diabetes, is related to the development of several diabetic adverse effects, which lead to an elevation in oxidative stress and inflammation responses. Among the current therapeutic options, such as hypoglycemic drugs and insulin therapy, which have limitations, there has been much attention given to the use of traditional medicinal plant that modulate hyperglycemia, inflammation, improve oxidative stress, and prevent diabetes-induced complications. Therefore, the aim of the current study is to investigate whether the consumption of aqueous and ethanolic Rheum extractions improve insulin sensitivity, inflammation and oxidative status in subjects with T2DM. Sixty patients with T2DM (male and female) were recruited in this double-blind, randomized and controlled clinical trial from the Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran. The participants were randomly allocated into three groups aqueous extract (n = 20), ethanolic extract (n = 20) and control (n = 20) who were given three Rheum ribes capsules daily for 6 weeks. A significant elevation in the quantitative insulin-sensitivity check index (QUICKI) was observed at the end of study in the aqueous extracts (P = 0.03) and also ethanolic extracts (P = 0.01) of Rheum extract groups compared to initial values. At the end of study, there was also a significant reduction in levels of malondialdehyde (MDA) in ethanolic extracts (P = 0.002) compared to initial values; however, intervention with aqueous extracts had no effect on malondialdehyde. There was also a significant reduction of high sensitivity C-reactive protein in ethanolic extracts (