Formulation of Mouthwash Using Combined Herbal Extracts to Control the Predominant Oral Pathogens and Biofilm

Globally, oral disease is a major health problem, which affects the quality of life. The role of oral microflora in the oral diseases is well established. However, with the increase in the frequency of oral disease, the development of antimicrobial drug resistance to the existing drugs has insisted...

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Bibliographic Details
Published in:Journal of herbal medicine 2024-08, Vol.46, p.100905, Article 100905
Main Authors: Sakthivel, A., Sankaran, K., Rengasamy, G., Vishnu Priya, V., Sathishkumar, P.
Format: Article
Language:English
Subjects:
Antimicrobial activity
Herbal extracts
Microbial biofilm
Oral pathogens
Phytochemicals
Streptococcus mutans
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Summary:Globally, oral disease is a major health problem, which affects the quality of life. The role of oral microflora in the oral diseases is well established. However, with the increase in the frequency of oral disease, the development of antimicrobial drug resistance to the existing drugs has insisted on searching for alternative drugs from plant sources. Herein, herbal-based mouthwash is formulated to effectively control the dominant oral pathogens. The antimicrobial activity of plant extracts was evaluated against oral pathogens by zone of inhibition test. Mouthwash was formulated with one gram of each plant extracts (Rosa damascena flower petals, Coleus amboinicus leaves, Psidium guajava leaves, and Phyllanthus acidus fruits) in 10% ethanol. Antimicrobial efficacy of the formulated mouthwash was assessed against Streptococcus mutans, Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, and Candida albicans by standard protocol. Also, the antibiofilm effect of the formulated mouthwash was assessed against preformed S mutans biofilm and visualised using SEM and CLSM. The formulated mouthwash exhibits excellent broad-spectrum antimicrobial activity. The minimum inhibitory concentration result indicates that the susceptibility of the pathogens was found as follows: S aureus
ISSN:2210-8033
DOI:10.1016/j.hermed.2024.100905