Correlation study between spot urine protein-to-creatinine ratio and 24-hour urine protein measurement in 174 patients for proteinuria assessment

According to the US National Kidney Foundation K/DOQI Guidelines in 2000, under most circumstances, spot urine samples should be used to detect and monitor proteinuria in children and adults and timed collection is often unnecessary. However, its use is still not widely implemented in Hong Kong. We...

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Bibliographic Details
Published in:Hong Kong journal of nephrology 2011-10, Vol.13 (2), p.51-54
Main Authors: Siu, Wai Kwan, Mak, Chloe Miu, Lee, Han Chih Hencher, Tam, Sidney, Lee, Joseph, Chan, Tak Mao, Fung, Ka Shun Samuel, Tong, Kwok Lung Matthew, Chan, Yan Wo Albert
Format: Article
Language:English
Subjects:
24-hour urine protein
Proteinuria
Urine protein-to-creatinine ratio
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Summary:According to the US National Kidney Foundation K/DOQI Guidelines in 2000, under most circumstances, spot urine samples should be used to detect and monitor proteinuria in children and adults and timed collection is often unnecessary. However, its use is still not widely implemented in Hong Kong. We aimed to assess the correlation of spot urine protein-to-creatinine (Pr/Cr) ratio to 24-hour urine protein excretion in our local setting. This was a prospective study set in regional hospitals in Hong Kong. A total of 174 patients were recruited from 2007 to 2008. Spot urine Pr/Cr ratio and 24-hour urine protein measurements were determined. Linear regression model was used to fit and test the relationship between 24-hour urine protein excretion and the spot urine Pr/Cr ratio. Spot urine Pr/Cr ratio correlated well with 24-hour urine protein excretion ( r = 0.95, p 
ISSN:1561-5413
1876-4371
DOI:10.1016/j.hkjn.2011.09.003