NOVEL antioxidant and oxidant biomarkers related to sarcopenia in COPD

•Antioxidant capacity is associated with muscle mass and strength in COPD.•Blood levels of TRAP and AOPP are associated with sarcopenia in COPD.•COPD is characterized by more prevalence of sarcopenia and augmented antioxidant activity. The relation between oxidative stress (OS) and sarcopenia in COP...

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Bibliographic Details
Published in:Heart & lung 2021-01, Vol.50 (1), p.184-191
Main Authors: Sepúlveda-Loyola, Walter, de Castro, Larissa Araújo, Matsumoto, Andressa Keiko, Camillo, Carlos Augusto, Barbosa, Décio Sabbatini, Galvan, Carrie Chueiri Ramos, Probst, Vanessa Suziane
Format: Article
Language:English
Subjects:
Aged
Antioxidants
Aryldialkylphosphatase
Biomarkers
COPD
Female
Hand Strength
Humans
Male
Middle Aged
Oxidants
Oxidative stress
Pulmonary Disease, Chronic Obstructive - complications
Sarcopenia
Sarcopenia - diagnosis
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Summary:•Antioxidant capacity is associated with muscle mass and strength in COPD.•Blood levels of TRAP and AOPP are associated with sarcopenia in COPD.•COPD is characterized by more prevalence of sarcopenia and augmented antioxidant activity. The relation between oxidative stress (OS) and sarcopenia in COPD remains unknown. To analyze OS levels and its association with sarcopenia in COPD. Thirty-nine individuals with COPD (69±7years; 41%female) and thirty-five for the control group (69±7years; 43%female) were included. Advanced oxidation protein products (AOPP), paraoxonase-1 (PON1), superoxide dismutase activity (SOD), catalase dismutase activity (CAT), sulfhydryl group (SH), nitric oxide metabolites (NOX), total radical trapping antioxidant parameter (TRAP) were analysed. OS markers were correlated with handgrip and quadriceps strength, gait speed, skeletal muscle mass index, fat-free mass index, maximum inspiratory and expiratory pressure. European criteria were used to identify sarcopenia. In COPD, antioxidant capacity was correlated with muscle mass and strength (r from 0.5 to 0.64) P
ISSN:0147-9563
1527-3288
DOI:10.1016/j.hrtlng.2020.06.001