89-P

• Published in: Human immunology 2013-11, Vol.74, p.112-112
• Main Authors: Hoteit, Rouba, Shammaa, Dina, Khalek, Rabab Abdel, Mahfouz, Rami
• Format: Article
• Language: English
• Subjects: Allergy and Immunology
• ISSN: 0198-8859
• DOI: 10.1016/j.humimm.2013.08.164

Aim The aim is to study NK KIR genotpyes in symptomatic patients infected with H. pylori and in H. pylori negative patients. Methods KIR genotype was analysed for 101 Lebanese symptomatic patients (51 H. pylori -positive and 50 H. pylori -negative) using the KIR Genotyping SSP kit. Results KIR genotypic profile distribution among the 51 Lebanese patients with Helicobacter pylori is shown in Table 1 . The content of KIR genes ranged from 5 to 13 and as per Table 4, the AA, AB, and BB genotypes frequencies were, respectively, 43.14%, 41.18% and 15.68% with an A:B ratio of 1.76:1. Table 2 [figure1] shows the distribution of different KIR genotypes among the 50 Helicobacter pylori -negative Lebanese patients. The content of KIR genes ranged from 7 to 13 and, as per Table 4, the AA, AB, and BB genotypes frequencies were, respectively, 18%, 62%, and 20% with an A:B ratio of 0.96:1. [ Table 1 ] Conclusions Although there was no statistical significance in the difference between the KIR gene distributions among the two compared groups, we noticed a reduced distribution of A haplotype among the “H pylori negative” patients as compared to the “H. Pylori positive” group. This means that more activating genes (through a B haplotype) are present in the former group which may explain faster eradication of the organism.