OR42 Expanded thymic regulatory T cells (Tregs) have low class I HLA expression levels and are HLA-DR negative – Potential for ‘Off-The-Shelf’ Cellular Therapy?

Tregs modulate immune responses against alloantigens and are a promising therapeutic tool in organ transplantation. We previously showed that abundant CD25+FOXP3+Tregs can be isolated and expanded from discarded human thymuses, routinely removed during pediatric cardiac surgery, indicating potential...

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Published in:Human immunology 2017-09, Vol.78, p.40-40
Main Authors: Dijke, Esme, Hoeppli, Romy, Larsen, Ingrid, Rebeyka, Ivan, Ross, David, Levings, Megan, West, Lori
Format: Article
Language:English
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Summary:Tregs modulate immune responses against alloantigens and are a promising therapeutic tool in organ transplantation. We previously showed that abundant CD25+FOXP3+Tregs can be isolated and expanded from discarded human thymuses, routinely removed during pediatric cardiac surgery, indicating potential use of thymic Tregs as an ‘off-the-shelf’ tolerogenic therapy. Immunogenicity of allogenic therapeutic Tregs, however, is unclear. Here we studied HLA-ABC and -DR expression on expanded thymic Tregs compared to blood Tregs. Thymocytes were obtained from infant thymuses (age
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2017.06.048