P089 Suppression of a HLA-B encoded microrna upregulates the expression of heavy chain IGA (IGHA1) transcript in human primary B-cells

Our previous work has shown that theHLA-B encoded miR-6891-5p influences the expression of about 200 transcripts, including the transcript encoding for the heavy chain of IgA, in a B cell line. We showed that the expression of heavy chain of IgA was up-regulated when miR-6891-5p activity was suppres...

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Bibliographic Details
Published in:Human immunology 2018-10, Vol.79, p.127-127
Main Authors: Chitnis, Nilesh S., Hu, Taishan, Duke, Jamie, Henrickson, Sarah, Silverman, Michael, Kamoun, Malek, Johnson, F. Bradley, Monos, Dimitri S.
Format: Article
Language:English
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Summary:Our previous work has shown that theHLA-B encoded miR-6891-5p influences the expression of about 200 transcripts, including the transcript encoding for the heavy chain of IgA, in a B cell line. We showed that the expression of heavy chain of IgA was up-regulated when miR-6891-5p activity was suppressed (doi: 10.3389/fimmu.2017.00583). In this work we aimed to determine whether increased expression of heavy chain of IgA transcript is also possible by suppressing miR-6891-5p activity in human primary B-cells. Human primary B-cells from a total of 12 human volunteers were analyzed. One of the samples was from an IgA deficient patient (
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2018.07.148