Metal-mediated and metal-catalyzed hydrolysis of nitriles

• Published in: Inorganica Chimica Acta 2005, Vol.358 (1), p.1-21
• Main Authors: Kukushkin, Vadim Yu, Pombeiro, Armando J.L.
• Format: Article
• Language: English
• Subjects: acac, acetylacetonate; Ar, aryl; bpy, 2,2′-bipyridine; Bu, butyl; cod, 1,5-cyclooctadiene; Cp, cyclopentadienyl; DME, dimethoxyethane; dppe, 1,2-bis(diphenylphosphino)ethane; en, ethylenediamine; Et, ethyl; HOAc, acetic acid; Me, methyl; Ph, phenyl; Pr, propyl; py, pyridine; PzH, pyrazole; THF, tetrahydrofurane; tpy, 2,2′:6′2″-terpyridine
• ISSN: 0020-1693; 1873-3255
• DOI: 10.1016/j.ica.2004.04.029

The metal-mediated and/or metal-catalyzed reactions of RCN species are reviewed with particular emphasis on (i) various factors which affect the metal-mediated hydrolysis of organonitriles and (ii) unusual conversions of RCN species, yet underdeveloped and non-systematic, which invlove hydrolysis and lead to compounds of synthetic and/or pharmacological significance. The essential goals of this review are the following: ( i) to verify various factors which affect the metal-mediated hydrolysis of organonitriles; ( ii) to draw attention to unusual conversions of RCN species, yet underdeveloped and non-systematic, which involve hydrolysis and lead to compounds of synthetic and/or pharmacological significance. The metal-mediated and/or metal-catalyzed reactions of RCN species are surveyed and the experimental material on metal-mediated hydration of RCN species at diverse metal centers along the Periodic Table is summarized in a tabular form.