Synthesis, characterization, crystal structures and DNA binding studies of nickel(II) hydrazone complexes

A series of new nickel complexes contains the hydrazone ligands were synthesized and characterized. The DNA binding properties of the complexes were investigated by absorption spectroscopy and cyclic voltammetry methods. A series of octahedral and square-planar Ni(II) complexes have been synthesized...

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Bibliographic Details
Published in:Inorganica Chimica Acta 2010-11, Vol.363 (14), p.3685-3693
Main Authors: Chitrapriya, Nataraj, Mahalingam, Viswanathan, Zeller, Matthias, Natarajan, Karuppannan
Format: Article
Language:English
Subjects:
Cyclic voltammetry
DNA-binding
Hydrazones
Ni(II)
Octahedral
Square-planar
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Summary:A series of new nickel complexes contains the hydrazone ligands were synthesized and characterized. The DNA binding properties of the complexes were investigated by absorption spectroscopy and cyclic voltammetry methods. A series of octahedral and square-planar Ni(II) complexes have been synthesized from two different types of hydrazone ligands. The isolated complexes have been characterized by means of analytical and spectroscopic techniques. The structures of two of the complexes have been determined by single crystal X-ray diffraction study. The binding modes of the complexes with DNA and their ability to bind DNA have been investigated by UV–Vis absorption titration, ethidium bromide fluorescence displacement experiments, and viscometry measurements and cyclic voltammetry studies. The experimental results show that the mode of binding of the complexes to DNA is combination of different mode of interaction.
ISSN:0020-1693
1873-3255
DOI:10.1016/j.ica.2010.05.017